局限性青少年牙周炎患者中性粒细胞中二酰甘油水平及代谢的改变
Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis.
作者信息
Tyagi S R, Uhlinger D J, Lambeth J D, Champagne C, Van Dyke T E
机构信息
Department of Biochemistry, Emory University Medical School, O. Wayne Rollins Research Center, Atlanta, Georgia 30322.
出版信息
Infect Immun. 1992 Jun;60(6):2481-7. doi: 10.1128/iai.60.6.2481-2487.1992.
Abstract
Diacylglycerol, a physiological activator of protein kinase C, was elevated nearly twofold in unstimulated peripheral blood neutrophils from patients with localized juvenile periodontitis compared with cells from normal individuals. These cells also showed an enhanced and prolonged elevation of diglyceride in response to N-formylmethionylleucylphenylalanine. The metabolism of a cell-permeant diacylglycerol by diglyceride kinase was significantly decreased, because of a fivefold or higher elevation in the apparent Km of cellular diglyceride kinase.
摘要
二酰甘油是蛋白激酶C的一种生理激活剂，与正常个体的细胞相比，局限性青少年牙周炎患者未受刺激的外周血中性粒细胞中的二酰甘油水平升高了近两倍。这些细胞对N-甲酰甲硫氨酰亮氨酰苯丙氨酸的反应也显示出二酰甘油水平增强且持续时间延长。由于细胞中二酰甘油激酶的表观Km升高了五倍或更高，二酰甘油激酶对一种细胞可渗透的二酰甘油的代谢显著降低。
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