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青少年牙周炎作为中性粒细胞功能的模型：补体趋化片段C5a的结合减少。

Juvenile periodontitis as a model for neutrophil function: reduced binding of the complement chemotactic fragment, C5a.

作者信息

Van Dyke T E, Levine M J, Tabak L A, Genco R J

出版信息

J Dent Res. 1983 Aug;62(8):870-2. doi: 10.1177/00220345830620080301.

DOI:10.1177/00220345830620080301
PMID:6575033
Abstract

The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.

摘要

使用碘化人C5a和快速离心测定法，对局限性青少年牙周炎（LJP）患者和正常对照者外周血中性粒细胞上趋化补体片段C5a的结合进行了定量分析。患者组中性粒细胞上每个细胞的结合位点数显著减少，而结合亲和力与对照值保持相同。

相似文献

1
Juvenile periodontitis as a model for neutrophil function: reduced binding of the complement chemotactic fragment, C5a.青少年牙周炎作为中性粒细胞功能的模型：补体趋化片段C5a的结合减少。
J Dent Res. 1983 Aug;62(8):870-2. doi: 10.1177/00220345830620080301.
2
Role of the neutrophil in oral disease: receptor deficiency in leukocytes from patients with juvenile periodontitis.中性粒细胞在口腔疾病中的作用：青少年牙周炎患者白细胞中的受体缺陷
Rev Infect Dis. 1985 May-Jun;7(3):419-25. doi: 10.1093/clinids/7.3.419.
3
Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro.中性粒细胞-内皮细胞相互作用。补体片段C5a、C5a去精氨酸产物以及甲酰甲硫氨酰亮氨酰苯丙氨酸在体外诱导中性粒细胞黏附性的调节。
J Clin Invest. 1984 Nov;74(5):1581-92. doi: 10.1172/JCI111574.
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1985 Kreshover lecture. Molecular factors influencing neutrophil defects in periodontal disease.1985年克雷肖弗讲座。影响牙周病中性粒细胞缺陷的分子因素。
J Dent Res. 1986 Dec;65(12):1379-91. doi: 10.1177/00220345860650120201.
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Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.Gc球蛋白（维生素D结合蛋白）增强C5a和C5a去精氨酸的中性粒细胞趋化活性。
J Clin Invest. 1988 Jul;82(1):364-9. doi: 10.1172/JCI113596.
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The polymorphonuclear leukocyte (PMNL) locomotor defect in juvenile periodontitis. Study of random migration, chemokinesis and chemotaxis.青少年牙周炎中多形核白细胞（PMNL）的运动缺陷。随机迁移、化学增活作用和趋化性的研究。
J Periodontol. 1982 Nov;53(11):682-7. doi: 10.1902/jop.1982.53.11.682.
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Role of chemotactic factor inactivator in modulating alveolar macrophage-derived neutrophil chemotactic activity.趋化因子灭活剂在调节肺泡巨噬细胞衍生的中性粒细胞趋化活性中的作用。
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Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation.脓毒症中的中性粒细胞功能障碍。II. 补体激活产物在细胞失活中作用的证据。
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Neutrophil function in patients with localized juvenile periodontitis and with rapidly progressive periodontitis.局限性青少年牙周炎和快速进展性牙周炎患者的中性粒细胞功能
J Biol Buccale. 1988 Sep;16(3):151-6.
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Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg.人外周血单核细胞对补体衍生肽C5a和C5a去精氨酸的趋化反应。
J Immunol. 1985 May;134(5):3325-31.

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J Indian Soc Periodontol. 2017 Nov-Dec;21(6):449-455. doi: 10.4103/jisp.jisp_107_17.
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Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature.
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Localized aggressive periodontitis is linked to human chromosome 1q25.局限性侵袭性牙周炎与人类1号染色体1q25区域相关。
Hum Genet. 2004 Feb;114(3):291-7. doi: 10.1007/s00439-003-1065-7. Epub 2003 Dec 12.
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Circulating promyelocytes and low levels of CD16 expression on polymorphonuclear leukocytes accompany early-onset periodontitis.循环早幼粒细胞以及多形核白细胞上低水平的CD16表达与早发性牙周炎相伴。
Infect Immun. 1997 Sep;65(9):3906-12. doi: 10.1128/iai.65.9.3906-3912.1997.
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Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis.局限性青少年牙周炎中中性粒细胞的钙依赖性蛋白激酶C活性
Infect Immun. 1993 Aug;61(8):3137-42. doi: 10.1128/iai.61.8.3137-3142.1993.
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Association of an abnormality of neutrophil chemotaxis in human periodontal disease with a cell surface protein.人类牙周病中中性粒细胞趋化异常与一种细胞表面蛋白的关联。
Infect Immun. 1987 Sep;55(9):2262-7. doi: 10.1128/iai.55.9.2262-2267.1987.
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Infect Immun. 1990 Apr;58(4):1085-92. doi: 10.1128/iai.58.4.1085-1092.1990.
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Infect Immun. 1992 Jun;60(6):2481-7. doi: 10.1128/iai.60.6.2481-2487.1992.