Correlation between antibodies to mannophosphoinositides & detection of antigen in circulating immune complexes in patients with pulmonary tuberculosis.

Enzyme linked immunosorbent assays were used to detect the concentration of mannophosphoinositides in circulating immune complexes (CICs) and antibodies to these antigens in the sera of patients with pulmonary tuberculosis. Serum samples from 235 tuberculosis patients at various levels of disease progression were analysed. Multiple regression analysis showed a direct correlation between antigen levels in CICs and serum antibodies to mannophosphoinositides.