O'Neill H J, Shirodaria P V
Department of Microbiology and Immunobiology, Royal Victoria Hospital, Belfast, U.K.
J Infect. 1992 May;24(3):301-9. doi: 10.1016/s0163-4453(05)80035-0.
Renal transplant patients with primary and recurrent cytomegalovirus (CMV) infection had higher antibody titres to Epstein-Barr virus viral capsid antigen (EBV-VCA-IgG) before and after transplantation than healthy blood donors. The geometric mean titres (GMT) of EBV-VCA-IgG were higher in renal transplant patients without CMV infection than in renal transplant patients with CMV infection. Four-fold or greater rises in EBV-VCA-IgG antibody were detected in six patients and a similar rise in antibody to EBV early antigen (EBV-EA-IgG) was detected in one other patient. IgM antibody to EBV-VCA (EBV-VCA-IgM) was detected in only three of these patients. EBV-EA-IgG was present in 39% patients and in 30% control subjects. IgG titres to varicella zoster virus (VZV-IgG) and rubella virus (rubella HI) were higher in patients without CMV infection compared to the patients with CMV infection. Raised titres were detected to VZV in five patients and to rubella virus in three patients. Reductions in antibody titre of four-fold or more were also detected in EBV-EA-IgG (one patient) and to rubella virus (one patient). Raised antibody titres to EBV, VZV, and rubella virus in renal transplant patients may indicate reactivation of these viruses without any symptoms.
与健康献血者相比，原发性和复发性巨细胞病毒（CMV）感染的肾移植患者在移植前后对EB病毒衣壳抗原（EBV-VCA-IgG）的抗体滴度更高。未感染CMV的肾移植患者中EBV-VCA-IgG的几何平均滴度（GMT）高于感染CMV的肾移植患者。在6例患者中检测到EBV-VCA-IgG抗体升高4倍或更多，在另外1例患者中检测到EB病毒早期抗原（EBV-EA-IgG）抗体有类似升高。在这些患者中只有3例检测到EBV-VCA的IgM抗体（EBV-VCA-IgM）。39%的患者和30%的对照受试者中存在EBV-EA-IgG。与感染CMV的患者相比，未感染CMV的患者中水痘带状疱疹病毒（VZV-IgG）和风疹病毒（风疹血凝抑制试验）的IgG滴度更高。在5例患者中检测到VZV滴度升高，在3例患者中检测到风疹病毒滴度升高。在1例患者中还检测到EBV-EA-IgG抗体滴度降低4倍或更多，在1例患者中检测到风疹病毒抗体滴度降低。肾移植患者中EBV、VZV和风疹病毒抗体滴度升高可能表明这些病毒在无任何症状的情况下重新激活。
