Tuppurainen K, Raninen A, Kosunen O, Kankkunen J P, Kellokoski J, Syrjänen S, Mäntyjärvi M, Syrjänen K
Department of Ophthalmology, University of Kuopio, Finland.
Acta Ophthalmol (Copenh). 1992 Apr;70(2):248-54. doi: 10.1111/j.1755-3768.1992.tb04132.x.
Squamous cell carcinoma of the conjunctiva is a distinct rarity, often arising at the corneoscleral limbus and initially resembling pterygium or chronic keratoconjunctivitis. In this paper we report 4 patients with conjunctival squamous cell carcinoma/carcinoma in situ, which comprise all the cases found in the files of Kuopio University Hospital during 1959-1991. The clinical appearance, diagnosis and treatment of the lesions are described. All biopsies were studied for the presence of Human papillomavirus (HPV) DNA (recently demonstrated in conjunctival squamous cell papillomas, precancer lesions and carcinomas) by using in situ DNA hybridization (ISH) and polymerase chain reaction (PCR). Both techniques failed to demonstrate the DNA of any of the following HPV types: HPV 6, 11, 16 and 18 in any of the lesions. The results are discussed in the light of the recently proposed HPV etiology of these lesions.
结膜鳞状细胞癌极为罕见，常发生于角膜缘，初起时类似翼状胬肉或慢性角结膜炎。本文报告了4例结膜鳞状细胞癌/原位癌患者，这些病例涵盖了1959年至1991年期间在库奥皮奥大学医院档案中发现的所有病例。文中描述了这些病变的临床表现、诊断及治疗情况。所有活检标本均采用原位DNA杂交（ISH）和聚合酶链反应（PCR）技术，检测人乳头瘤病毒（HPV）DNA的存在情况（最近在结膜鳞状细胞乳头状瘤、癌前病变及癌中均有发现）。两种技术均未能在任何病变中检测到以下任何一种HPV类型的DNA：HPV 6、11、16和18。本文根据最近提出的这些病变的HPV病因对结果进行了讨论。
