Odrich M G, Jakobiec F A, Lancaster W D, Kenyon K R, Kelly L D, Kornmehl E W, Steinert R F, Grove A S, Shore J W, Gregoire L
Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston.
Ophthalmology. 1991 May;98(5):628-35. doi: 10.1016/s0161-6420(91)32218-8.
Three patients with bilateral tumors presenting as multiple keratinizing and verrucous lesions of the bulbar and tarsal conjunctiva were determined by DNA amplification and hybridization studies to harbor human papillomavirus type 16 (HPV-16). Results of biopsy in two patients showed infiltrating squamous cell carcinoma in one eye and dysplasia or carcinoma in situ in the fellow eye. In the third patient, focal, inflamed, hypertrophic, papillary lesions with pseudoglandular invaginations of the surface epithelium were found in the tarsal conjunctivae of both eyes. These are the first documented cases of bilateral conjunctival tumors associated with human papillomavirus.
三名双侧肿瘤患者的球结膜和睑结膜出现多个角化性和疣状病变，通过DNA扩增和杂交研究确定其感染了16型人乳头瘤病毒（HPV-16）。两名患者的活检结果显示，一只眼睛为浸润性鳞状细胞癌，另一只眼睛为发育异常或原位癌。在第三名患者中，双眼睑结膜出现局灶性、炎症性、肥厚性、乳头状病变，表面上皮有假腺样内陷。这些是首批有文献记载的与人类乳头瘤病毒相关的双侧结膜肿瘤病例。
