Paya C V, Wiesner R H, Hermans P E, Larson-Keller J J, Ilstrup D M, Krom R A, Moore S B, Ludwig J, Smith T F
Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Hepatology. 1992 Jul;16(1):66-70. doi: 10.1002/hep.1840160113.
In this study we evaluated the association between cytomegalovirus infection alone or in relation to human leukocyte antigen matching and the development of vanishing bile duct syndrome, a form of chronic hepatic allograft rejection. A total of 81 consecutive liver transplant recipients were studied. Cytomegalovirus infection developed in 46 recipients (57%), and vanishing bile duct syndrome occurred in 9 recipients (11%). Cytomegalovirus infection developed in only five of the nine patients with vanishing bile duct syndrome. Univariate analysis of pretransplant recipient/donor cytomegalovirus serological tests and human leukocyte antigen typing showed they were not significant risk factors for the development of vanishing bile duct syndrome. Time-dependent analysis of cytomegalovirus infection after transplantation as a risk factor for vanishing bile duct syndrome, in a multivariate analysis with human leukocyte antigen match, showed no statistical significance. In our study, no association was found between cytomegalovirus infection alone or in relation to class I or II human leukocyte antigen match and the subsequent development of vanishing bile duct syndrome.
在本研究中，我们评估了单纯巨细胞病毒感染或与人类白细胞抗原匹配相关的巨细胞病毒感染与消失胆管综合征（一种慢性肝移植排斥反应形式）发生之间的关联。共研究了81例连续的肝移植受者。46例受者（57%）发生了巨细胞病毒感染，9例受者（11%）出现了消失胆管综合征。在9例患有消失胆管综合征的患者中，只有5例发生了巨细胞病毒感染。对移植前受者/供者巨细胞病毒血清学检测和人类白细胞抗原分型进行单因素分析显示，它们不是消失胆管综合征发生的显著危险因素。在将移植后巨细胞病毒感染作为消失胆管综合征危险因素的时间依赖性分析中，与人类白细胞抗原匹配进行多因素分析，结果无统计学意义。在我们的研究中，未发现单纯巨细胞病毒感染或与I类或II类人类白细胞抗原匹配相关的巨细胞病毒感染与随后消失胆管综合征的发生之间存在关联。
