STABLEFORTH A W
Bull World Health Organ. 1954;10(6):927-35.
In field trials on the eradication of brucellosis from dairy herds in Great Britain, which began in 1933, a serum standard of reference was used for the examination of agglutinating suspensions prepared in different laboratories. In 1937, the Office International des Epizooties (OIE) adopted this standard and made recommendations for its use internationally. These recommendations were revised by OIE in 1948, by the Third Inter-American Congress on Brucellosis and by the Joint FAO/WHO Expert Panel on Brucellosis in 1950, and again by the latter body in 1952. A new batch equivalent in potency to the original standard was established by the WHO Expert Committee on Biological Standardization in 1952 as the International Standard for Anti-Brucella abortus Serum.The International Standard, or a national standard of equivalent potency, ensures comparability of the titres obtained in different countries by different methods, and the results of such comparisons can be expressed in a simple manner by describing the titres in terms of International Units of Brucella antibody.
在1933年开始的英国奶牛场布鲁氏菌病根除现场试验中，使用了一种血清标准品来检测不同实验室制备的凝集悬浮液。1937年，国际兽疫局（OIE）采用了该标准并就其在国际上的使用提出了建议。这些建议在1948年由国际兽疫局、1950年由第三届美洲布鲁氏菌病大会以及粮农组织/世卫组织布鲁氏菌病联合专家小组进行了修订，1952年后者再次进行了修订。1952年，世卫组织生物标准化专家委员会确立了一批效价与原标准相当的新批次产品作为抗流产布鲁氏菌血清国际标准品。国际标准品或效价相当的国家标准品可确保不同国家通过不同方法获得的效价具有可比性，通过以布鲁氏菌抗体国际单位来描述效价，此类比较结果能够以简单的方式呈现。
