JERNE N K
Bull World Health Organ. 1954;10(6):937-40.
The agglutinating activity of individual sera is usually expressed by a "titre" notation, the titre being dependent on the degree of agglutination arbitrarily chosen as the end-point. This titre may be corrected by comparison with a standard serum. A "unit" notation, however, necessarily requires both comparative measurements in relation to a standard serum and the taking into consideration of all degrees of agglutination. This involves log-dose-response curves for the standard serum and the test serum; and cases in which the distance between such curves is not constant, either at different degrees of agglutination or where different antigen suspensions are used, will bring to light fundamental limitations of the bio-assay which the simple use of titres may not reveal.
个体血清的凝集活性通常用“滴度”表示，滴度取决于任意选定为终点的凝集程度。该滴度可通过与标准血清比较来校正。然而，“单位”表示法必然需要与标准血清进行比较测量，并考虑所有凝集程度。这涉及标准血清和测试血清的对数剂量反应曲线；而且，在不同凝集程度或使用不同抗原悬液时，此类曲线之间的距离不恒定的情况，将揭示生物测定法的基本局限性，而简单使用滴度可能无法揭示这些局限性。
