Narita T
First Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
Nihon Shokakibyo Gakkai Zasshi. 1992 May;89(5):1252-9.
Using with the newly modified perchloric acid pretreatment method and endotoxin specific assay (Endospecy), the plasma endotoxin in the patients with liver cirrhosis was investigated. The mean value of plasma endotoxin in control (n = 20) was below 9.8 pg/ml. The plasma endotoxin level in liver cirrhosis was 5.7 +/- 5.3 pg/ml (n = 70, mean +/- SD), and 20% of the patients (15 cases) showed above 9.8 pg/ml. Endotoxin level significantly correlated with the severity of liver function based on the Child-Turcotte classification (p less than 0.01). Plasma endotoxin positively correlated with total bilirubin (r = 0.417) and ICG clearance test (r = 0.298) and negatively correlated with prothrombin time (%) (r = 0.497) and HDL-cholesterol (r = 0.578) in the patients with liver cirrhosis. There was no correlation between esophageal varices and plasma endotoxin level. Plasma endotoxin was slightly detected in the patients with decompensated cirrhosis, and these data suggest that plasma endotoxin level in cirrhosis is not so elevated.
采用新改良的高氯酸预处理方法和内毒素特异性检测法（Endospecy），对肝硬化患者的血浆内毒素进行了研究。对照组（n = 20）血浆内毒素的平均值低于9.8 pg/ml。肝硬化患者的血浆内毒素水平为5.7 +/- 5.3 pg/ml（n = 70，平均值 +/- 标准差），20%的患者（15例）高于9.8 pg/ml。根据Child-Turcotte分类，内毒素水平与肝功能严重程度显著相关（p < 0.01）。肝硬化患者血浆内毒素与总胆红素（r = 0.417）和吲哚菁绿清除试验（r = 0.298）呈正相关，与凝血酶原时间（%）（r = 0.497）和高密度脂蛋白胆固醇（r = 0.578）呈负相关。食管静脉曲张与血浆内毒素水平之间无相关性。失代偿期肝硬化患者血浆中可轻微检测到内毒素，这些数据表明肝硬化患者血浆内毒素水平并未显著升高。
