Renegar K B
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
Lab Anim Sci. 1992 Jun;42(3):222-32.
Studies of the pathogenesis of influenza infection have involved the extensive use of animal models. The development of the current concepts of immunity to influenza and of the contribution the secretory immune system makes toward the protection of mucosal surfaces against influenza infection would have been impossible without this use of animals. The pathology and clinical signs of influenza infection in both natural and experimental hosts, the advantages and disadvantages of the most common experimental influenza infection models, and the contribution of animal models to the understanding of local and systemic immunity to influenza infection are discussed.
流感感染发病机制的研究广泛使用了动物模型。如果没有对动物的这种利用，就不可能形成当前关于流感免疫的概念以及分泌免疫系统对保护黏膜表面免受流感感染所起的作用。本文讨论了自然宿主和实验宿主中流感感染的病理学和临床症状、最常见的实验性流感感染模型的优缺点，以及动物模型对理解流感感染的局部和全身免疫的贡献。
