Hubbard G B, Soike K F, Butler T M, Carey K D, Davis H, Butcher W I, Gauntt C J
Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.
Lab Anim Sci. 1992 Jun;42(3):233-9.
Approximately 80 baboon deaths were caused by encephalomyocarditis virus (EMCV) infection in a 3060 member research and production colony. The epizootic extended over a 9-month period and occurred in baboons ranging from 1 day to 22 years of age. Acute death was the most common history. When clinical disease was detected, it was characterized by labored respiration associated with acute congestive heart failure. The salient necropsy findings were pulmonary congestion and edema, hydropericardium, hydrothorax, ascites, lymph node and splenic hypertrophy, and pale white-to-tan mottled hearts. The most significant histologic lesion was nonsuppurative necrotizing myocarditis. Placental infection with fetal loss occurred. Diagnosis was confirmed by light microscopy, transmission electron microscopy, virus culture, and serology. Rarely, EMCV-induced antibody persisted in surviving baboons for more than 24 months. EMCV-infected feral rats were the probable source of the virus and their control stopped the epizootic. No EMCV neutralizing antibody was detected in colony support personnel or chimpanzees.
在一个拥有3060只狒狒的研究与繁殖群体中，约80只狒狒死于脑心肌炎病毒（EMCV）感染。这次 epizootic 持续了9个月，发生在年龄从1天到22岁的狒狒身上。急性死亡是最常见的情况。当检测到临床疾病时，其特征为与急性充血性心力衰竭相关的呼吸费力。尸检的显著发现包括肺充血和水肿、心包积水、胸腔积液、腹水、淋巴结和脾脏肿大，以及心脏呈淡白色至棕褐色的斑驳状。最显著的组织学病变是非化脓性坏死性心肌炎。发生了胎盘感染并导致胎儿死亡。通过光学显微镜、透射电子显微镜、病毒培养和血清学确诊。存活的狒狒中，很少有EMCV诱导的抗体持续超过24个月。感染EMCV的野生大鼠可能是病毒来源，对其进行控制后 epizootic 得以终止。在群体支持人员或黑猩猩中未检测到EMCV中和抗体。 （注：“epizootic”这个词在原文中可能是笔误，推测应为“epidemic”，即流行病，译文按正确推测进行了翻译调整，如果原文就是这个词，可按“ epizootic”直接保留，其意思为“动物流行病” ）
