Koenen F, Vanderhallen H, Castryck F, Miry C
Veterinary and Agrochemic Research Center (CODA/CERVA), Ukkel, Belgium.
Zentralbl Veterinarmed B. 1999 May;46(4):217-31.
In 1991 EMCV was isolated for the first time in Belgium from the offspring of a sow with reproductive failure. From August 1995 until December 1996, EMCV was diagnosed in 154 Belgian pig holdings in association with myocardial failure and sudden death in fatteners and suckling piglets or with reproductive failure in sows. To clarify some epidemiological aspects 3 EMCV isolates characteristic for the different clinical pictures and outbreaks were studied. Field observations and animal experiments indicated that the pathogenicity induced by each isolate is specific for one age category and that the spread of the virus is limited. The presented data also suggest that rodents may play a role in the transmission of EMCV but that pig-to-pig transmission is at least as important. Molecular analysis of two separate regions on the genomes of the respective EMCV isolates showed that the 1995-96 EMCV epizootic in Belgium was due to a new virus introduction. Furthermore, the VP1 coding gene is proposed as a marker of virulence.
1991年，在比利时首次从一头患有繁殖障碍的母猪后代中分离出了脑心肌炎病毒（EMCV）。从1995年8月到1996年12月，在比利时的154个猪场诊断出了EMCV，这些猪场出现育肥猪和哺乳仔猪的心肌衰竭和猝死，或母猪的繁殖障碍。为了阐明一些流行病学方面的问题，对3株具有不同临床症状和疫情特征的EMCV分离株进行了研究。现场观察和动物实验表明，每株分离株诱导的致病性对一个年龄组具有特异性，并且病毒传播有限。所提供的数据还表明，啮齿动物可能在EMCV的传播中起作用，但猪与猪之间的传播至少同样重要。对各EMCV分离株基因组上两个不同区域的分子分析表明，1995 - 1996年比利时的EMCV流行是由于新病毒的引入。此外，VP1编码基因被提议作为毒力的标志物。
