McCarthy A L, Malik Peiris J S, Taylor C E, Green M A, Sviland L, Pearson A D, Malcolm A J
Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne.
J Clin Pathol. 1992 Jun;45(6):542-4. doi: 10.1136/jcp.45.6.542.
An allogeneic transplant recipient developed severe graft versus host disease (GvHD) 48 days after transplantation that was concomitant with a cytomegalovirus (CMV) viraemia, from which she subsequently died. CMV infection was detected in blood by the polymerase chain reaction and later in tissue by immunohistochemical techniques. CMV should be considered in patients in whom GvHD does not respond to appropriate treatment, and this case suggests that herpes viruses may increase the severity of GvHD by synergistically enhancing the graft versus host reaction.
一名异基因移植受者在移植后48天发生了严重的移植物抗宿主病（GvHD），同时伴有巨细胞病毒（CMV）血症，随后死亡。通过聚合酶链反应在血液中检测到CMV感染，后来通过免疫组织化学技术在组织中检测到。对于GvHD对适当治疗无反应的患者应考虑CMV感染，该病例表明疱疹病毒可能通过协同增强移植物抗宿主反应而增加GvHD的严重程度。
