Dubovsky S L, Murphy J, Christiano J, Lee C
Department of Psychiatry, University of Colorado School of Medicine, Denver.
J Neuropsychiatry Clin Neurosci. 1992 Winter;4(1):3-14. doi: 10.1176/jnp.4.1.3.
Studies of aberrations in second messenger function may help to elucidate some of the multiple complex neurobiological alterations in bipolar affective disorders. The phosphatidylinositol and calcium ion (Ca2+) second messengers are of particular interest because of evidence of hyperactivity of these signaling mechanisms in both mania and bipolar depression and of their normalization by lithium and other mood-stabilizing treatments. Because the intracellular Ca2+ signal has a biphasic action, a single aberration could explain diverse clinical manifestations of the same illness, and a single action on the messenger could explain the biphasic actions of many treatments for bipolar disorders.
对第二信使功能异常的研究可能有助于阐明双相情感障碍中多种复杂的神经生物学改变。磷脂酰肌醇和钙离子（Ca2+）第二信使特别受关注，因为有证据表明这些信号传导机制在躁狂和双相抑郁中均存在活性亢进，且锂盐和其他心境稳定剂治疗可使其恢复正常。由于细胞内Ca2+信号具有双相作用，单一异常可能解释同一疾病的不同临床表现，而对信使的单一作用可能解释双相情感障碍多种治疗方法的双相作用。
