Gratama J W, Oosterveer M A, Lepoutre J, Fibbe W E, Ringdén O, Vossen J M, Willemze R, Bolhuis R L, van Rood J J, Ernberg I
Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands.
Ann Hematol. 1992 Jun;64 Suppl:A162-5. doi: 10.1007/BF01715373.
The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We have shown that EBV may be eradicated from some BMT recipients and that the virus may be transferred with the marrow graft. During the immediate post-transplant period oropharyngeal EBV excretion may occur which, by infecting passing B lymphocytes, may act as co-factor for acute graft-versus-host disease and help the virus to survive, despite the temporary depletion of its reservoir. The coexistence of totally different EBV strains in BMT recipients but not in healthy, untransfused controls, suggests that superinfection may by possible in case of immunodeficiency; alternatively, transfer of the virus by the reservoir itself (the B lymphocytes) might be the only effective route for superinfection. The generation of 'variant' strains during viral replication may form the basis of the vast polymorphism between wild-type EBV isolates in the population.
异体骨髓移植（BMT）会严重扰乱爱泼斯坦-巴尔病毒（EBV）与宿主之间的关系，因为EBV存在于受者的造血系统中（在大多数情况下该系统必须被破坏），也存在于供者的造血系统即骨髓移植物中。我们已经表明，EBV可能会从一些BMT受者体内被清除，并且该病毒可能会随骨髓移植物一起转移。在移植后的即刻阶段，可能会出现口咽EBV排泄，通过感染路过的B淋巴细胞，这可能作为急性移植物抗宿主病的协同因子，并帮助病毒存活，尽管其储存库暂时耗竭。BMT受者中存在完全不同的EBV毒株，而健康未输血的对照中则不存在，这表明在免疫缺陷情况下可能发生重叠感染；或者，病毒通过储存库本身（B淋巴细胞）转移可能是重叠感染的唯一有效途径。病毒复制过程中“变异”毒株的产生可能构成人群中野生型EBV分离株之间巨大多态性的基础。
