Stoltz J F, Streiff F, Nicolas A, Alexandre P, Larcan A
C R Seances Soc Biol Fil. 1975;169(6):1424-8.
The action of polylysines of various molecular weight on platelet behaviour is studied with the help of 3 techniques: photometric test, screen filtration pressure on PRP and electrophoretic mobility. Polylysines, which are polybasic substances, produce a platelet aggregation studied by photometry after a short period of latency. Aggregation, depending on the doses of poly-lysine and chiefly on the optic density, shows a "plateau" with the dose of 100 gamma/ml for poly-lysine L, of molecular weight 17000. The screen filtration pressure increases continuously in the presence of the polylysines studies. Finally, the platelet charge decreases. The results depend on the concentration of poly-lysine, and the optimal concentration which involves the more marked alterations is inversely proportional to the molecular weight of the polylysine studied.
光度测试、富血小板血浆的筛滤压力和电泳迁移率。聚赖氨酸是多碱性物质，经过短时间潜伏期后，通过光度法可观察到其会引起血小板聚集。聚集情况取决于聚赖氨酸的剂量，主要取决于光密度，对于分子量为17000的聚赖氨酸L，在剂量为100γ/ml时出现“平台期”。在所研究的聚赖氨酸存在的情况下，筛滤压力持续增加。最后，血小板电荷减少。结果取决于聚赖氨酸的浓度，引起最显著变化的最佳浓度与所研究的聚赖氨酸的分子量成反比。
