Valette G, Ribes G, Loubatières-Mariani M M, Loubatières A L
C R Seances Soc Biol Fil. 1975;169(6):1562-7.
The chronic oral administration of phenformin (20 mg/kg daily during 8 days) to the normal concious dog provokes a decrease in the fasting thiamine levels of plasma and erythrocytes. During intragastric loading tests with thiamine hydrochloride (30 mg/kg), carried out during the chronic treatment with the biguanide, the curve of plasma hyperthiaminemia is increased. The authors suggest an explanation for these apparently contradictory results.
对正常清醒犬每日口服苯乙双胍（8天内每天20毫克/千克）会导致血浆和红细胞中空腹硫胺素水平降低。在用双胍类药物进行慢性治疗期间，进行盐酸硫胺素（30毫克/千克）的胃内负荷试验时，血浆硫胺素血症曲线升高。作者对这些明显矛盾的结果提出了解释。
