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[对不同应激暴露抵抗力和脑单胺水平的大鼠学习与探索行为的比较分析]

[A comparative analysis of learning and exploratory behavior in rats with different resistances to stress exposures and to the brain monoamine level].

作者信息

Ismaĭlova Kh Iu, Semenova T P, Fast A E, Gasanov G G, Gromova E A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 May-Jun;42(3):518-26.

PMID:1323178
Abstract

Wistar rats stable (S) to sound stimulus differed from the unstable (NS) ones by a heightened investigatory activity in condition of moderate stress in the open field test, by heightened reactivity to sensory stimuli of various modalities (somatosensory, visual and olfactory), lowered level of investigatory behaviour in the test of burrow chamber. S-rats differed from NS-animals by a higher ability to learning of goal-directed reaction and a lower ability to discrimination of different emotional influences. The results of biochemical analysis of the content of biogenic amines in various brain structures revealed in stable rats an increase of noradrenaline level and in non-stable ones--a higher level of dopamine and serotonin.

摘要

对声音刺激稳定(S)的Wistar大鼠与不稳定(NS)大鼠的区别在于,在旷场试验中中等应激条件下探究活动增强,对各种感觉刺激(躯体感觉、视觉和嗅觉)的反应性增强,在洞穴试验中探究行为水平降低。S大鼠与NS动物的区别在于,前者学习目标导向反应的能力较高,而区分不同情绪影响的能力较低。对各种脑结构中生物胺含量的生化分析结果显示,稳定大鼠去甲肾上腺素水平升高,而非稳定大鼠多巴胺和血清素水平较高。

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