Gromova E A, Semenova T P, Gasanov G G, Ismaĭlova Kh Iu, Fast A E, Nesterova I V
Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 Mar-Apr;40(2):301-9.
The influences of 6-OHDA (150 mcg intraventricular, bilaterally) on the behaviour of Wistar rats with different resistance to sound-stress were studied. Reduction of reactivity, exploratory activity and learning deterioration after 6-OHDA administration were observed. The behavioural disturbances were more demonstrative in stress-resistant rats. Biochemical estimations showed that 6-OHDA induced a reduction of brain noradrenaline level in stress-resistant rats and a reduction of dopamine level in nonresistant animal. It is suggested that more demonstrative behavioural disturbances induced by 6-OHDA in stress-resistant rats are connected with deficit of brain noradrenaline.
研究了6-羟基多巴胺（双侧脑室内注射150微克）对不同声应激抗性的Wistar大鼠行为的影响。观察到给予6-羟基多巴胺后反应性降低、探索活动减少以及学习能力下降。行为障碍在应激抗性大鼠中更为明显。生化评估表明，6-羟基多巴胺导致应激抗性大鼠脑去甲肾上腺素水平降低，非抗性动物脑多巴胺水平降低。有人认为，6-羟基多巴胺在应激抗性大鼠中引起的更明显的行为障碍与脑去甲肾上腺素缺乏有关。
