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[新皮质额叶区域的儿茶酚胺能神经支配在调节对声音应激具有不同抵抗力的大鼠行为中的作用]

[The role of the catecholaminergic innervation of the neocortical frontal area in regulating the behavior of rats with differing resistance to acoustic stress].

作者信息

Gasanov G G, Ismaĭlova Kh Iu, Gromova E A, Semenova T P, Nesterova I V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Sep-Oct;45(5):1006-13.

PMID:8560918
Abstract

Influence of 6-OHDA (40 mcg) injection in the frontal neocortex on behaviour was studied in Wistar rats with different resistance to sound-induced stress. Reduction of exploratory activity in the open field, reactivity to stimuli of different modality and deterioration of food-procuring conditioning were observed after 6-OHDA treatment of stress-resistant rats. On the contrary, treatment of non-resistant rats with 6-OHDA increased the reactivity to stimuli of different modality and the learning capacity. Thus, catecholaminergic system of the frontal neocortex is differently involved in the regulation of cognitive processes in stress-resistant and non-resistant rats.

摘要

研究了向具有不同声音诱导应激抗性的Wistar大鼠额叶新皮质注射6-羟基多巴胺(40微克)对行为的影响。对应激抗性大鼠进行6-羟基多巴胺处理后,观察到旷场中探索活动减少、对不同模态刺激的反应性降低以及获取食物条件反射能力下降。相反,用6-羟基多巴胺处理非抗性大鼠则增加了对不同模态刺激的反应性和学习能力。因此,额叶新皮质的儿茶酚胺能系统在应激抗性和非抗性大鼠认知过程的调节中发挥着不同的作用。

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Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Sep-Oct;45(5):1006-13.
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