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1
The antigenic potency of non-infectious poliomyelitis virus as determined by its liberating effect on active virus neutralized by immune serum.通过其对被免疫血清中和的活性病毒的释放作用所测定的非感染性脊髓灰质炎病毒的抗原效力。
J Exp Med. 1955 Mar 1;101(3):331-9. doi: 10.1084/jem.101.3.331.
2
ANTIGENIC VARIATIONS AMONG TYPE III POLIOMYELITIS VIRUSES.III型脊髓灰质炎病毒中的抗原变异
N Y State J Med. 1964 Aug 15;64:2058-65.
3
The preparation of specific immune sera against type 3 poliovirus D-antigen and C-antigen and the demonstration of two C-antigenic components in vaccine strain populations.抗3型脊髓灰质炎病毒D抗原和C抗原特异性免疫血清的制备以及疫苗株群体中两种C抗原成分的证明。
J Gen Virol. 1980 Nov;51(Pt 1):147-56. doi: 10.1099/0022-1317-51-1-147.
4
[Use of monoclonal antibodies for the intratypic differentiation of strains of poliomyelitis type I virus].[单克隆抗体在脊髓灰质炎I型病毒株型内鉴别中的应用]
Vopr Virusol. 1987 Mar-Apr;32(2):183-8.
5
THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.脊髓灰质炎病毒中和抗体的形成与特性。II. 19S和7S抗体的形成：持续合成、回忆反应及对X射线照射敏感性方面抗原剂量需求的差异
J Exp Med. 1964 Jan 1;119(1):21-39. doi: 10.1084/jem.119.1.21.
6
Intratypic characterization of poliovirus type 1 isolates.脊髓灰质炎病毒1型分离株的型内特征分析
Indian J Med Res. 1991 Jul;93:202-7.
7
Antigenic analysis of poliovirus type 3 using monoclonal antibodies.使用单克隆抗体对3型脊髓灰质炎病毒进行抗原分析。
Dev Biol Stand. 1984;57:151-5.
8
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
9
Immunological and pathogenic properties of poliovirus variants selected for resistance to antiviral drug V-073.对抗病毒药物V - 073产生抗性的脊髓灰质炎病毒变体的免疫学和致病特性
Antivir Ther. 2011;16(7):999-1004. doi: 10.3851/IMP1838.
10
The application of tissue cultures to the preparation and assay of viral antibodies.组织培养在病毒抗体制备与检测中的应用。
Ann N Y Acad Sci. 1954 Nov 17;58(7):1072-84. doi: 10.1111/j.1749-6632.1954.tb45893.x.

引用本文的文献

1
[The kinetic reaction of sero-neutralization of poliomyelitis virus].[脊髓灰质炎病毒血清中和的动力学反应]
Bull World Health Organ. 1959;20(4):563-78.
2
The determination of antigenic potency of poliomyelitis vaccine by measuring its antibody-combining capacity.通过测量脊髓灰质炎疫苗的抗体结合能力来确定其抗原效力。
Bull World Health Organ. 1960;22(3-4):307-11.
3
[Determination of the antigenic value of poliomyelitis vaccine].[脊髓灰质炎疫苗抗原价值的测定]
Bull World Health Organ. 1960;22(3-4):295-305.
4
Potency of poliomyelitis vaccines estimated by an antibody combining test.通过抗体结合试验评估脊髓灰质炎疫苗的效力。
J Bacteriol. 1960 Jul;80(1):111-8. doi: 10.1128/jb.80.1.111-118.1960.
5
Neutralizing-antibody-combining (NAC) test for measuring antigenic potency of poliomyelitis vaccine.用于测定脊髓灰质炎疫苗抗原效力的中和抗体结合（NAC）试验。
Bull World Health Organ. 1959;20(6):1075-98.
6
Detection of respiratory syncytial virus in nasopharyngeal secretions by inhibition of enzyme-linked immunosorbent assay.通过酶联免疫吸附试验抑制法检测鼻咽分泌物中的呼吸道合胞病毒。
J Clin Microbiol. 1981 Nov;14(5):510-5. doi: 10.1128/jcm.14.5.510-515.1981.

本文引用的文献

1
The use of adjuvants to facilitate studies on the immunologic classification of poliomyelitis viruses.使用佐剂以促进对脊髓灰质炎病毒免疫分类的研究。
Am J Hyg. 1951 Sep;54(2):157-73. doi: 10.1093/oxfordjournals.aje.a119474.
2
Immunization of cotton rats with inactivated Lansing poliomyelitis virus. I. Inactivation by chemical agents.用灭活的兰辛脊髓灰质炎病毒对棉鼠进行免疫。I. 化学试剂灭活
Am J Hyg. 1951 Mar;53(2):121-30. doi: 10.1093/oxfordjournals.aje.a119439.
3
Studies in human subjects on active immunization against poliomyelitis. II. A practical means for inducing and maintaining antibody formation.关于人类脊髓灰质炎主动免疫的研究。II. 诱导和维持抗体形成的实用方法。
Am J Public Health Nations Health. 1954 Aug;44(8):994-1009. doi: 10.2105/ajph.44.8.994.
4
Formaldehyde treatment and safety testing of experimental poliomyelitis vaccines.实验性脊髓灰质炎疫苗的甲醛处理及安全性测试
Am J Public Health Nations Health. 1954 May;44(5):563-70. doi: 10.2105/ajph.44.5.563.
5
Preparation and standardization of antiserums prepared with the three known types to poliomyelitis viruses.用三种已知类型的脊髓灰质炎病毒制备抗血清及其标准化
Am J Hyg. 1954 Mar;59(2):221-35. doi: 10.1093/oxfordjournals.aje.a119635.
6
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
7
Antibody response of chimpanzees and human beings to formalin-inactivated trivalent poliomyelitis vaccine.黑猩猩和人类对甲醛灭活三价脊髓灰质炎疫苗的抗体反应。
Am J Hyg. 1952 Nov;56(3):265-86. doi: 10.1093/oxfordjournals.aje.a119551.
8
Immunization of mice with inactivated type 2 poliomyelitis virus against types 2 and 3 viruses.用灭活的脊髓灰质炎2型病毒对小鼠进行免疫以抵抗2型和3型病毒。
Proc Soc Exp Biol Med. 1952 Aug-Sep;80(4):731-6. doi: 10.3181/00379727-80-19745.

通过其对被免疫血清中和的活性病毒的释放作用所测定的非感染性脊髓灰质炎病毒的抗原效力。

The antigenic potency of non-infectious poliomyelitis virus as determined by its liberating effect on active virus neutralized by immune serum.

作者信息

KRECH U

出版信息

J Exp Med. 1955 Mar 1;101(3):331-9. doi: 10.1084/jem.101.3.331.

DOI:10.1084/jem.101.3.331
PMID:13233455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2136467/
Abstract

The activation of poliomyelitis virus from a "neutral" virus-antibody mixture by the addition of non-infectious virus is described. The phenomenon was demonstrated in tissue cultures using both Petri dishes and roller tubes. The reaction was found to be type-specific and a relationship between antigen dilution and number of plaques counted was established. The relative potency of vaccine preparations determined in this system was found to be comparable to their relative potency in respect to protection-inducing activity in mice.

摘要

本文描述了通过添加非感染性病毒，将脊髓灰质炎病毒从“中和”的病毒-抗体混合物中激活的过程。该现象在使用培养皿和滚瓶的组织培养中得到了证实。发现该反应具有型特异性，并建立了抗原稀释与所计数的蚀斑数量之间的关系。在该系统中测定的疫苗制剂的相对效力被发现与其在小鼠中诱导保护活性方面的相对效力相当。