从尿酸结石中分离并鉴定尿酸素。

Isolation and characterization of uricine from uric acid stones.

作者信息

Pinto B, Rocha E, Ruiz-Marcellán F J

出版信息

Kidney Int. 1976 Dec;10(6):437-43. doi: 10.1038/ki.1976.130.

DOI:10.1038/ki.1976.130

Abstract

Uricine was found to be present in all uric acid stones tested, although another physiochemically related pigment was occasionally present. Uricine is of low molecular weight (28.2) and a preliminary analysis of its structure suggests that it is formed by two pyrrolic rings. It is a yellow pigment whose color is pH-dependent, shifting from reddish-yellow to green at pH 1.0. It is water soluble, but its solubility increases in alkaline solutions. Preliminary evidence suggests that uricine is related metabolically to bilirubin-like compounds.

摘要

在所检测的所有尿酸结石中均发现存在尿酸素，不过偶尔也会出现另一种与物理化学相关的色素。尿酸素分子量较低（28.2），对其结构的初步分析表明它由两个吡咯环构成。它是一种黄色色素，其颜色取决于pH值，在pH 1.0时从红黄色变为绿色。它可溶于水，但其溶解度在碱性溶液中会增加。初步证据表明尿酸素在代谢上与胆红素样化合物有关。