Yamanishi K, Kondo K, Mukai T, Kondo T, Nagafuji H, Kato T, Okuno T, Kurata T
Department of Virology, Osaka University, Japan.
Acta Paediatr Jpn. 1992 Jun;34(3):337-43. doi: 10.1111/j.1442-200x.1992.tb00969.x.
Human herpesvirus 6 (HHV 6) was isolated from patients with exanthema subitum (ES) with a high frequency, and it is now believed that this virus causes ES as a primary infection in childhood. HHV 6 infection is highly prevalent in early childhood and this virus may infect infants through the saliva mainly from mother to child. HHV 6 has a tropism to CD4+ cells and destroys cells in vitro. Although children recover from ES without any sequelae, neurological symptoms associated with exanthema subitum are often observed, and we could detect HHV 6 in the cerebrospinal fluid of ES patients. This result suggests that HHV 6 may invade the central nervous system and cause neurological symptoms.
人类疱疹病毒6型（HHV - 6）在幼儿急疹（ES）患者中被高频分离出来，现在人们认为这种病毒在儿童期作为原发性感染引发幼儿急疹。HHV - 6感染在幼儿期非常普遍，这种病毒可能主要通过母亲的唾液从母婴传播感染婴儿。HHV - 6对CD4 +细胞具有嗜性，并在体外破坏细胞。尽管儿童从幼儿急疹中康复且无任何后遗症，但常观察到与幼儿急疹相关的神经症状，并且我们能够在幼儿急疹患者的脑脊液中检测到HHV - 6。这一结果表明HHV - 6可能侵入中枢神经系统并引起神经症状。
