Dager S R, Marro K I, Richards T L, Metzger G D
Department of Psychiatry, University of Washington, School of Medicine, Harborview Medical Center, Seattle 98104.
Life Sci. 1992;51(12):973-85. doi: 10.1016/0024-3205(92)90404-d.
Proton magnetic resonance spectroscopy (1H MRS) localized to the left temporal-parietal region in 8 healthy volunteers detected a 2.1-fold +/- 0.7-fold increase (all values +/-SD) in brain lactate during intravenous infusion of 0.5 molar (M) sodium lactate (5 meq/kg over 20 minutes). Significant increases in brain lactate occurred within 5-10 minutes after starting lactate infusion, progressively rose during the infusion, then decreased towards baseline levels during 30 minutes post-infusion. Venous lactate concentration increased from 0.8 +/- 0.2 mM to 10.9 +/- 4.1 mM or 13.6-fold during the infusion. Flow phantom findings in vitro suggest attenuation of 1H MRS blood lactate signal from arteries and veins as a result of flow velocity effects. Correlations between paired blood and brain lactate measurements at each sampling time indicate a non-linear relationship between compartments during lactate infusion.
在8名健康志愿者中，对左颞顶叶区域进行质子磁共振波谱分析（1H MRS）发现，静脉输注0.5摩尔（M）乳酸钠（20分钟内输注5毫当量/千克）期间，脑内乳酸水平增加了2.1倍±0.7倍（所有数值±标准差）。开始输注乳酸后5 - 10分钟内脑内乳酸显著增加，输注过程中逐渐上升，然后在输注后30分钟内降至基线水平。输注期间静脉乳酸浓度从0.8±0.2毫摩尔/升增加到10.9±4.1毫摩尔/升，即增加了13.6倍。体外流动模型研究结果表明，由于流速效应，动脉和静脉的1H MRS血乳酸信号减弱。每次采样时间点配对的血液和脑内乳酸测量值之间的相关性表明，乳酸输注期间各腔室之间存在非线性关系。
