Dager S R, Marro K I, Richards T L, Metzger G D
Department of Psychiatry, University of Washington, Seattle.
Biol Psychiatry. 1992 Nov 15;32(10):913-21. doi: 10.1016/0006-3223(92)90180-8.
Proton magnetic resonance spectroscopy (1H MRS) performed in vivo on nine Sprague Dawley rats detected a threefold increase in whole brain lactate during intravenous 1 mol/L sodium lactate infusion. Significant increases in whole brain lactate were detected within 5 min after starting lactate infusion, progressively rose to a maximum level estimated at 3.2 +/- 1.5 mmol/L (all values +/- SD) immediately postinfusion, then decreased towards baseline levels during the next hr. Venous lactate concentration, increasing from 2.3 +/- 2.4 mmol/L to 43.0 +/- 8.0 mmol/L during the infusion, exhibited a steeper rise and then decreased more rapidly in comparison to changes in whole brain lactate. These data suggest MRS can be used in vivo to study acute changes in brain lactate associated with increasing blood lactate concentrations.
对9只斯普拉格-道利大鼠进行的体内质子磁共振波谱分析（1H MRS）检测到，在静脉输注1 mol/L乳酸钠期间，全脑乳酸增加了两倍。在开始输注乳酸后的5分钟内，检测到全脑乳酸显著增加，在输注后立即逐渐上升至估计为3.2±1.5 mmol/L的最高水平（所有值±标准差），然后在接下来的1小时内降至基线水平。静脉血乳酸浓度在输注期间从2.3±2.4 mmol/L增加到43.0±8.0 mmol/L，与全脑乳酸的变化相比，上升更为陡峭，随后下降得更快。这些数据表明，MRS可用于体内研究与血乳酸浓度升高相关的脑乳酸急性变化。
