Sukumaran M, Gowda K, Maiya P P, Srinivas T P, Kumar M S, Aijaz S, Reddy R R, Padilla L, Greenberg H B, Rao C D
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore.
Arch Virol. 1992;126(1-4):239-51. doi: 10.1007/BF01309698.
A large number of stool specimens, of healthy newborn infants, collected from various hospitals and clinics in Bangalore City, India, have been examined for the presence of asymptomatic rotaviral excretion. Out of 370 samples analysed during a three year period from 1988 to 1991, 133 specimens (36%) were positive for rotavirus RNA. All these asymptomatic neonatal strains, without exception, showed "long" RNA pattern, but subgroup I specificity. Serotype analysis by ELISA or by hybridization with serotype-specific probes indicated that these strains probably represent a new serotype in newborn children. We find an exclusive association of human rotaviruses having "long" RNA pattern and subgroup I specificity with asymptomatic neonatal infections in contrast to the earlier observations of association of such unusual strains with acute gastroenteritis in young children.
从印度班加罗尔市的多家医院和诊所收集了大量健康新生儿的粪便样本，以检测无症状轮状病毒排泄情况。在1988年至1991年的三年期间分析的370份样本中，133份标本（36%）轮状病毒RNA呈阳性。所有这些无症状的新生儿毒株无一例外都显示出“长”RNA模式，但具有I亚组特异性。通过ELISA或与血清型特异性探针杂交进行的血清型分析表明，这些毒株可能代表新生儿中的一种新血清型。我们发现，与早期观察到的此类异常毒株与幼儿急性胃肠炎的关联相反，具有“长”RNA模式和I亚组特异性的人类轮状病毒与无症状新生儿感染存在排他性关联。
