Dijk D J, Brunner D P, Aeschbach D, Tobler I, Borbély A A
Institute of Pharmacology, University of Zurich, Switzerland.
Neuropsychopharmacology. 1992 Nov;7(3):225-32.
A single dose of ethanol (0.60 g/kg of body weight) was administered to eight young healthy male subjects 35 minutes before bedtime. Compared to the average value of two baseline nights, subjective sleep and polysomnographically determined sleep parameters were not significantly affected. In the first 2 hours of sleep after ethanol intake, the combined value of wakefulness, stage 1, and movement time was reduced. In this interval, visually scored stage 4 sleep was increased, and electroencephalographic (EEG) power density in nonrapid-eye-movement (nonREM) sleep was enhanced in the lowest delta frequencies and reduced in the beta range. Computed for the entire sleep episode, power density in REM sleep was enhanced in some theta frequencies. In the sleep episode initiated 24 hours after ethanol intake, power density in nonREM and REM sleep was enhanced in delta and theta frequencies, and the subjectively perceived number of awakenings was reduced. The effects of ethanol on EEG power spectra during sleep differ from those published for benzodiazepine and nonbenzodiazepine hypnotics. This indicates that the effects of ethanol on the human sleep EEG are not mediated by the benzodiazepine receptor.
在睡前35分钟给8名年轻健康男性受试者单次服用乙醇（0.60克/千克体重）。与两个基线夜晚的平均值相比，主观睡眠和多导睡眠图测定的睡眠参数未受到显著影响。在摄入乙醇后的前2小时睡眠中，清醒、1期睡眠和活动时间的总和减少。在此时间段内，视觉评分的4期睡眠增加，非快速眼动（nonREM）睡眠中的脑电图（EEG）功率密度在最低的δ频率范围内增强，在β频率范围内降低。在整个睡眠阶段进行计算，快速眼动（REM）睡眠中的一些θ频率的功率密度增强。在摄入乙醇24小时后开始的睡眠阶段，非快速眼动和快速眼动睡眠中的δ和θ频率的功率密度增强，主观感觉到的觉醒次数减少。乙醇对睡眠期间脑电图功率谱的影响与已发表的苯二氮䓬类和非苯二氮䓬类催眠药的影响不同。这表明乙醇对人类睡眠脑电图的影响不是由苯二氮䓬受体介导的。
