Landolt H P, Roth C, Dijk D J, Borbély A A
Institute of Pharmacology, University of Zürich, Switzerland.
J Clin Psychopharmacol. 1996 Dec;16(6):428-36. doi: 10.1097/00004714-199612000-00004.
The effect of a moderate dose of ethanol (0.55 g/kg of body weight), administered 6 hours before scheduled bedtime, on performance, nocturnal sleep, and the sleep electroencephalogram (EEG) was investigated in 10 healthy, middle-aged men (mean age: 61.6 +/- 0.9 years). By the beginning of the sleep episode, breath-ethanol concentrations had declined to zero in all subjects. Compared with the control condition (mineral water), sleep was perceived as more superficial. Sleep efficiency, total sleep time, stage 1, and rapid eye movement (REM) sleep were reduced. In the second half of the sleep episode, wakefulness exhibited a twofold increase. EEG power density in low delta frequencies was enhanced in non-REM sleep (1.25-2.5 Hz) and REM sleep (1.25-1.5 Hz). In slow wave sleep (i.e., stages 3 + 4), power density was increased not only in the low-frequency range (1.25-1.5, 2.25-4.0, 4.75-5.0 Hz) but also within the alpha (8.25-9.0 Hz) and sigma (12.25-13.0 Hz) band. The data demonstrate that late-afternoon ethanol intake in middle-aged men disrupts sleep consolidation, affects the sleep stage distribution, and alters the sleep EEG.
在10名健康中年男性（平均年龄：61.6±0.9岁）中，研究了在预定就寝时间前6小时给予中等剂量乙醇（0.55克/千克体重）对其表现、夜间睡眠及睡眠脑电图（EEG）的影响。到睡眠开始时，所有受试者的呼气乙醇浓度均已降至零。与对照情况（饮用矿泉水）相比，睡眠被认为更浅。睡眠效率、总睡眠时间、第1阶段睡眠和快速眼动（REM）睡眠均减少。在睡眠阶段的后半段，清醒次数增加了两倍。在非快速眼动睡眠（1.25 - 2.5赫兹）和快速眼动睡眠（1.25 - 1.5赫兹）中，低δ频率的脑电图功率密度增强。在慢波睡眠（即第3 + 4阶段）中，功率密度不仅在低频范围（1.25 - 1.5、2.25 - 4.0、4.75 - 5.0赫兹）增加，而且在α（8.25 - 9.0赫兹）和σ（12.25 - 13.0赫兹）频段内也增加。数据表明，中年男性在傍晚摄入乙醇会破坏睡眠巩固、影响睡眠阶段分布并改变睡眠脑电图。
