Niimura M
Department of Dermatology, Jikei University School of Medicine, Tokyo, Japan.
Hum Cell. 1992 Jun;5(2):160-6.
Human papillomaviruses (HPV) generally associated with benign skin and anogenital warts. Because several of skin cancers were found to contain HPV-DNA, it has been speculated that certain types of HPV could be specifically associated with cancers. Although HPV-DNAs are not isolated from most of skin cancers, they are often isolated from penile cancers, vulval cancers and anogenital Bowen's diseases. Patients with epidermodysplasia verruciformis start to suffer from disseminated incurable warts during their childhood, and some of these benign lesions often convert to skin cancer in adulthood. Although the disease is very rare, HPV may also play a role in malignant transformation in epidermodysplasia verruciformis. More than 60 types of HPVs distinguished by molecular hybridization techniques. The type of HPV determines the clinical picture of wart and natural fate of HPV-associated lesion. There are two groups of HPVs, which are benign types and malignant types. Viral DNA of malignant type of HPV transforms human keratinocytes in vitro, and the transforming activity has been mapped to the E6 and E7 genes.
人乳头瘤病毒（HPV）通常与良性皮肤疣和肛门生殖器疣有关。由于发现一些皮肤癌含有HPV-DNA，因此推测某些类型的HPV可能与癌症有特定关联。虽然大多数皮肤癌中未分离出HPV-DNA，但它们经常在阴茎癌、外阴癌和肛门生殖器鲍温病中被分离出来。疣状表皮发育不良患者在童年时期开始出现播散性无法治愈的疣，其中一些良性病变在成年期常转变为皮肤癌。虽然这种疾病非常罕见，但HPV在疣状表皮发育不良的恶性转化中可能也起作用。通过分子杂交技术已鉴定出60多种HPV类型。HPV的类型决定了疣的临床表现以及HPV相关病变的自然转归。HPV有两组，即良性型和恶性型。恶性型HPV的病毒DNA在体外可转化人角质形成细胞，其转化活性已定位到E6和E7基因。
