Seidell J C, Muller D C, Sorkin J D, Andres R
Laboratory of Clinical Physiology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Int J Obes Relat Metab Disord. 1992 Sep;16(9):667-74.
The authors followed 775 men (aged 18-98 years) participating in the Baltimore Longitudinal Study in Aging for an average of ten years. Resting metabolic rate and fasting respiratory exchange ratio (RER) were measured by indirect calorimetry on their first visit and related to subsequent weight change. Deviations from the predicted value of resting metabolic rates (predicted from their estimated fat-free mass) were calculated. Average weight change was 0.07 kg (s.d. 6.4 kg); 122 men (15.3%) gained more than 5 kg and 40 (5.2%) more than 10 kg during the follow-up. After adjustment for initial age, body mass index, fat-free mass, and duration of follow-up, RER, but not RMR or deviations from predicted RMR, was positively related to weight change (P less than 0.001). Major weight gain (from at least 5 kg to at least 15 kg) was related to initial RER in non-obese men only (initial body mass index less than 25 kg/m2). From Cox proportional hazard regression analyses the adjusted relative risk of gaining 5 kg or more in initially non-obese men with a fasting RER of 0.85 or more was calculated to be 2.42 (95% confidence interval: 1.10-5.32) compared to men with a fasting RER less than 0.76. It was concluded that a relatively high fasting RER is a weak but significant predictor of substantial weight gain in non-obese white men.
作者对参与巴尔的摩纵向衰老研究的775名男性（年龄在18 - 98岁之间）进行了平均为期十年的跟踪研究。在他们首次就诊时，通过间接测热法测量静息代谢率和空腹呼吸交换率（RER），并将其与随后的体重变化相关联。计算静息代谢率与预测值（根据其估计的去脂体重预测）的偏差。平均体重变化为0.07千克（标准差6.4千克）；在随访期间，122名男性（15.3%）体重增加超过5千克，40名（5.2%）体重增加超过10千克。在对初始年龄、体重指数、去脂体重和随访时间进行调整后，RER与体重变化呈正相关（P小于0.001），而静息代谢率或静息代谢率与预测值的偏差则不然。只有非肥胖男性（初始体重指数小于25千克/平方米）的大幅体重增加（至少5千克至至少15千克）与初始RER有关。通过Cox比例风险回归分析计算得出，空腹RER为0.85或更高的初始非肥胖男性体重增加5千克或更多的调整后相对风险为2.42（95%置信区间：1.10 - 5.32），而空腹RER小于0.76的男性则为1。研究得出结论，相对较高的空腹RER是非肥胖白人男性体重显著增加的一个微弱但显著的预测指标。
