Van Ranst M, Kaplan J B, Burk R D
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
J Gen Virol. 1992 Oct;73 ( Pt 10):2653-60. doi: 10.1099/0022-1317-73-10-2653.
Human papillomaviruses (HPVs) are a heterogeneous group of small dsDNA viruses which cause a variety of proliferative epithelial lesions at specific anatomical sites. Although more than 65 different virus types have been cloned and characterized, no uniform classification system exists. In order to classify HPV DNA types, phylogenetic trees were constructed based on nucleotide sequence alignments using parsimony and distance matrix algorithms. The resulting phylogenetic trees provide a classification of the HPVs into specific groups encompassing the known tissue tropism and oncogenic potential of each HPV type. The implications of a phylogenetic taxonomy on the diagnostic detection of HPVs and the concept of different HPV species are discussed.
人乳头瘤病毒（HPV）是一组异质性的小双链DNA病毒，可在特定解剖部位引起多种增生性上皮病变。尽管已克隆并鉴定出65种以上不同的病毒类型，但尚无统一的分类系统。为了对HPV DNA类型进行分类，使用简约法和距离矩阵算法，基于核苷酸序列比对构建了系统发育树。所得的系统发育树将HPV分为特定的组，涵盖了每种HPV类型已知的组织嗜性和致癌潜力。本文讨论了系统发育分类法对HPV诊断检测的意义以及不同HPV物种的概念。
