Garbuglia Anna Rosa
Laboratory of Virology, "L. Spallanzani" National Institute for Infectious Diseases, Via Portuense, 292, 00149 Rome, Italy.
Cancers (Basel). 2014 Aug 18;6(3):1705-26. doi: 10.3390/cancers6031705.
Human papillomavirus (HPV) is currently considered to be a major etiologic factor, in addition to tobacco and alcohol, for oropharyngeal cancer (OPC) development. HPV positive OPCs are epidemiologically distinct from HPV negative ones, and are characterized by younger age at onset, male predominance, and strong association with sexual behaviors. HPV16 is the most prevalent types in oral cavity cancer (OCC), moreover the prevalence of beta, and gamma HPV types is higher than that of alpha HPV in oral cavity.
人乳头瘤病毒（HPV）目前被认为是除烟草和酒精外，导致口咽癌（OPC）发生的主要病因。HPV阳性的OPC在流行病学上与HPV阴性的OPC不同，其特征为发病年龄较轻、男性居多，且与性行为密切相关。HPV16是口腔癌（OCC）中最常见的类型，此外，β和γ型HPV在口腔中的患病率高于α型HPV。
