Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
Virology. 2013 Oct;445(1-2):213-23. doi: 10.1016/j.virol.2013.05.007. Epub 2013 May 25.
We provide an overview of the host range, taxonomic classification and genomic diversity of animal papillomaviruses. The complete genomes of 112 non-human papillomavirus types, recovered from 54 different host species, are currently available in GenBank. The recent characterizations of reptilian papillomaviruses extend the host range of the Papillomaviridae to include all amniotes. Although the genetically diverse papillomaviruses have a highly conserved genomic lay-out, deviations from this prototypic genome organization are observed in several animal papillomaviruses, and only the core ORFs E1, E2, L2 and L1 are present in all characterized papillomavirus genomes. The discovery of papilloma-polyoma hybrids BPCV1 and BPCV2, containing a papillomaviral late region but an early region encoding typical polyomaviral nonstructural proteins, and the detection of recombination breakpoints between the early and late coding regions of cetacean papillomaviruses, could indicate that early and late gene cassettes of papillomaviruses are relatively independent entities that can be interchanged by recombination.
我们提供了动物乳头瘤病毒的宿主范围、分类学分类和基因组多样性的概述。目前，GenBank 中可获得来自 54 种不同宿主物种的 112 种非人类乳头瘤病毒类型的完整基因组。最近对爬行动物乳头瘤病毒的特征描述将乳头瘤病毒科的宿主范围扩展到包括所有羊膜动物。尽管遗传上多样化的乳头瘤病毒具有高度保守的基因组结构，但在几种动物乳头瘤病毒中观察到偏离这种原型基因组组织的情况，并且并非所有特征描述的乳头瘤病毒基因组中都存在核心 ORF E1、E2、L2 和 L1。乳头瘤-多瘤杂交体 BPCV1 和 BPCV2 的发现，包含乳头瘤病毒晚期区域，但早期区域编码典型的多瘤病毒非结构蛋白，以及在鲸目乳头瘤病毒的早期和晚期编码区域之间检测到重组断点，可能表明乳头瘤病毒的早期和晚期基因盒是相对独立的实体，可以通过重组互换。
