Girlanda P, Vita G, Nicolosi C, Milone S, Messina C
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.
J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):844-5. doi: 10.1136/jnnp.55.9.844.
To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients injected with BoTox (Oculinum(R) 20-130 units) for craniocervical dystonia and hemifacial spasm. Patients underwent two sessions of treatment and the second time the dosage was doubled. Botulinum toxin injection induced an increase of mean jitter value above normal limits in all cases. An increase of fibre density was recorded six weeks after the treatment. Cardiovascular reflexes showed mild abnormalities in four patients. The data confirm distant effects of botulinum toxin on neuromuscular transmission and on autonomic function.
为评估肉毒杆菌毒素的远隔效应，对5例因颅颈肌张力障碍和半面痉挛而注射肉毒杆菌毒素（Oculinum® 20 - 130单位）的患者，进行了指总伸肌单纤维肌电图检查及六项心血管反射测试。患者接受了两个疗程的治疗，第二次治疗时剂量加倍。肉毒杆菌毒素注射在所有病例中均导致平均颤抖值升高至正常范围以上。治疗六周后记录到纤维密度增加。四名患者的心血管反射显示出轻度异常。这些数据证实了肉毒杆菌毒素对神经肌肉传递和自主神经功能的远隔效应。
