Jamieson G A, Maitland N J, Wilcock G K, Yates C M, Itzhaki R F
Department of Optometry and Vision Sciences, UMIST, Manchester, U.K.
J Pathol. 1992 Aug;167(4):365-8. doi: 10.1002/path.1711670403.
We have investigated the possible involvement of viruses, specifically Herpes simplex virus type 1, in senile dementia of the Alzheimer type (SDAT). Using the highly sensitive polymerase chain reaction, we have detected the viral thymidine kinase gene in post-mortem brain from 14/21 cases of senile dementia of the Alzheimer type and 9/15 elderly normals. The temporal cortex and hippocampus were usually virus-positive; in contrast, the occipital cortex was virus-negative in 9/9 SDAT cases and 5/5 elderly normals. Temporal and frontal cortex from younger normals (five infants and five middle-aged) were negative. Thus, the presence of Herpes simplex virus type 1 DNA is a region-dependent feature of the aged brain.
我们研究了病毒，特别是1型单纯疱疹病毒，在阿尔茨海默型老年性痴呆（SDAT）中可能的作用。通过使用高度灵敏的聚合酶链反应，我们在21例阿尔茨海默型老年性痴呆患者中的14例以及15例老年正常对照中的9例的尸检大脑中检测到了病毒胸苷激酶基因。颞叶皮质和海马通常呈病毒阳性；相比之下，在9例SDAT患者和5例老年正常对照中，枕叶皮质均为病毒阴性。较年轻正常对照（5名婴儿和5名中年人）的颞叶和额叶皮质为阴性。因此，1型单纯疱疹病毒DNA的存在是老年大脑的一个区域依赖性特征。
