[新型苯二氮䓬衍生物吉达西泮与乙胺碘呋酮对不同起源心律失常的抗心律失常作用及电生理效应的比较分析]
[Comparative analysis of antiarrhythmic action and electrophysiological effects of a new benzodiazepine derivative gidazepam and ethacizin in arrhythmias of various genesis].
作者信息
Skibitskiĭ V V, Petrova T R, Kanorskiĭ S G
出版信息
Kardiologiia. 1992 Jun;32(6):35-7.
The antiarrhythmic and electrophysiological effects of the new benzodiazepine tranquilizer gidazepam versus ethacizin were examined in patients with cardiac arrhythmias. The antiarrhythmic effect of the agent was found during 24-day monitoring and simulated psychoemotional stress in 81% of patients with neurocirculatory dystonia and in 61% of patients with coronary heart disease. The antiarrhythmic effects developed with gidazepam-induced changes in electrophysiological properties of the cardiac conduction system. The preventive antiarrhythmic effect of gidazepam was demonstrated to be higher than that of ethacizin during stress in patients with arrhythmias of extra-ischemic genesis.
在心律失常患者中，对新型苯二氮䓬类镇静剂吉地西泮与乙吗噻嗪的抗心律失常和电生理作用进行了研究。在对81%的神经循环性肌张力障碍患者和61%的冠心病患者进行的为期24天的监测及模拟心理情绪应激期间，发现了该药物的抗心律失常作用。吉地西泮的抗心律失常作用是随着心脏传导系统电生理特性的改变而产生的。在非缺血性起源心律失常患者应激期间，吉地西泮的预防性抗心律失常作用被证明高于乙吗噻嗪。
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