Flodmark C E, Henningsen N C, Sveger T
Department of Pediatrics, University of Lund, Malmö General Hospital, Sweden.
Miner Electrolyte Metab. 1992;18(1):6-8.
Principally to ascertain whether mineral metabolism is involved in weight regulation, the 40 most obese of 1,774 children, aged 10-11 years, screened for obesity were compared with 46 age-matched controls. The obese children had more 3H-Ouabain erythrocyte binding sites (p = 0.04), higher intracellular sodium (p = 0.04), and lower plasma sodium (p = 0.002). After exclusion of the non-Scandinavians, the p values were p = 0.02, p = 0.03, and p = 0.03, respectively. Analysis of variance also showed the differences to be more dependent on obesity than on gender or nationality. It is concluded that obese children have more 3H-Ouabain erythrocyte binding sites indicating an increase of the sodium-potassium adenosine triphosphatase activity. The increase of intracellular sodium may increase the risk of future hypertension.
主要为了确定矿物质代谢是否参与体重调节，在1774名接受肥胖筛查的10至11岁儿童中，将40名最肥胖的儿童与46名年龄匹配的对照组儿童进行了比较。肥胖儿童具有更多的3H-哇巴因红细胞结合位点（p = 0.04）、更高的细胞内钠水平（p = 0.04）和更低的血浆钠水平（p = 0.002）。排除非斯堪的纳维亚人后，p值分别为p = 0.02、p = 0.03和p = 0.03。方差分析还表明，这些差异更多地取决于肥胖，而非性别或国籍。研究得出结论，肥胖儿童具有更多的3H-哇巴因红细胞结合位点，这表明钠钾三磷酸腺苷酶活性增加。细胞内钠的增加可能会增加未来患高血压的风险。
