Beutler E, Kuhl W, Sacks P
N Engl J Med. 1983 Sep 29;309(13):756-60. doi: 10.1056/NEJM198309293091303.
Previous investigations have suggested that red-cell ouabain binding (an indirect measure of sodium-potassium-ATPase activity) is lower in severely obese patients than in normal controls. We now confirm that ouabain binding measures sodium-potassium-ATPase activity, and we demonstrate that the level of this activity is genetically determined. The activity of this enzyme differs in various ethnic and racial groups, relatively high levels being encountered in non-Jewish white subjects, particularly those with some Scandinavian ancestry. On the other hand, black, Asian, and Jewish white subjects have lower sodium-potassium-ATPase activity. In contrast, no difference was found in red-cell sodium-potassium-ATPase activity between severely obese and normal persons, nor could we confirm a putative effect of food intake on the level of the red-cell enzyme. We suggest that in most earlier studies in which differences were found between normal and severely obese persons, those differences could have been due to differences in the ethnic origins of the obese and control populations.
以往的研究表明，严重肥胖患者红细胞哇巴因结合力（钠钾 - ATP酶活性的间接指标）低于正常对照组。我们现在证实，哇巴因结合力可衡量钠钾 - ATP酶活性，并且证明该活性水平是由基因决定的。这种酶的活性在不同的种族和民族群体中存在差异，在非犹太白人受试者中相对较高，尤其是那些有一些斯堪的纳维亚血统的人。另一方面，黑人、亚洲人和犹太白人受试者的钠钾 - ATP酶活性较低。相比之下，严重肥胖者与正常人的红细胞钠钾 - ATP酶活性没有差异，我们也无法证实食物摄入对红细胞酶水平有假定的影响。我们认为，在大多数早期研究中发现正常人与严重肥胖者之间存在差异，这些差异可能是由于肥胖人群和对照人群的种族起源不同所致。
