Poulos E T, Tedesco F J
Arch Dermatol. 1976 Jul;112(7):974-6. doi: 10.1001/archderm.112.7.974.
A double-blind prospective study was undertaken to compare low-dosage tetracycline hydrochloride and clindamycin hydrate hydrochloride in the treatment of patients with pustular acne. Clinical improvement was noted in 93.7% of those receiving tetracycline and in 92.8% of those receiving clindamycin. Of those patients who were receiving clindamycin, two patients developed diarrhea and one patient developed pseudomembranous colitis. We conclude, therefore, that clindamycin should not be used as a primary drug in the treatment of acne.
进行了一项双盲前瞻性研究，以比较低剂量盐酸四环素和盐酸克林霉素水合物治疗脓疱性痤疮患者的效果。接受四环素治疗的患者中有93.7%临床症状改善，接受克林霉素治疗的患者中有92.8%临床症状改善。在接受克林霉素治疗的患者中，有两名患者出现腹泻，一名患者出现假膜性结肠炎。因此，我们得出结论，克林霉素不应作为治疗痤疮的首选药物。
