Basler R S
Cutis. 1980 May;25(5):527-8.
Tetracycline, because of its effectiveness, safety, and economy, remains the treatment of choice for chronic maintenance of uncomplicated acne. However, a certain percentage of patients with very difficult acne will not respond satisfactorily to tetracycline. The study presented herein described forty-two patients with nodulocystic acne who did not show imporvement on adequate trials of tetracycline and were switched to low-dose clindamycin. A majority of these patients then showed significant improvement with nine showing essential clearing of the condition. Two patients experienced diarrhea, but recovered immediately after the clindamycin was discontinued.
由于四环素的有效性、安全性和经济性，它仍然是单纯性痤疮慢性维持治疗的首选药物。然而，一定比例的重度痤疮患者对四环素治疗反应不佳。本文所呈现的研究描述了42例结节囊肿性痤疮患者，他们在充分试用四环素后病情未改善，转而使用低剂量克林霉素治疗。这些患者中的大多数随后病情显著改善，其中9例基本痊愈。2例患者出现腹泻，但在停用克林霉素后立即康复。
