Christian G L, Krueger G G
Arch Dermatol. 1975 Aug;111(8):997-1000.
Eighty-three patients with moderately severe acne were entered into a double-blind study utilizing clindamycin and placebo. Counts of comedones and pustules were made at intervals during a 13-week period. Clindamycin resulted in noticeable improvement of acne in 85% of subjects while in the placebo group improvement was present in 38%. There was also an unexplained reduction of total comedone count in the clindamycin-treated group. Severe side effects occurred in two of 44 patients receiving clindamycin (diarrhea, 1 and rash, 1); although an additional eight patients receiving clindamycin experienced mild diarrhea, discontinuation of therapy was not required. Clindamycin appears to be a valuable additional drug in the treatment of acne.
83名中度严重痤疮患者参与了一项使用克林霉素和安慰剂的双盲研究。在13周期间定期对粉刺和脓疱进行计数。克林霉素使85%的受试者痤疮有明显改善，而安慰剂组改善率为38%。在接受克林霉素治疗的组中，粉刺总数也出现了无法解释的减少。44名接受克林霉素治疗的患者中有2人出现严重副作用（腹泻1例，皮疹1例）；另外8名接受克林霉素治疗的患者出现轻度腹泻，但无需停药。克林霉素似乎是治疗痤疮的一种有价值的辅助药物。
