阿奇霉素对米色小鼠鸟分枝杆菌感染的活性。
Activity of azithromycin against Mycobacterium avium infection in beige mice.
作者信息
Cynamon M H, Klemens S P
机构信息
Veterans Affairs Medical Center, Syracuse, New York.
出版信息
Antimicrob Agents Chemother. 1992 Aug;36(8):1611-3. doi: 10.1128/AAC.36.8.1611.
Abstract
The comparative activities of azithromycin and clarithromycin and the activities of azithromycin alone and in combination with other antimycobacterial agents were evaluated in the beige mouse model of disseminated Mycobacterium avium complex infection. Azithromycin was similar in activity to clarithromycin. Azithromycin plus clofazimine plus ethambutol reduced the number of splenic organisms more than azithromycin alone, while the combination was less active than azithromycin alone for bacteria in lungs. Rifabutin had activity similar to that of azithromycin for organisms in spleens and lungs. Rifabutin plus azithromycin was more active than either agent alone for organisms in spleens, but the combination's activity was not significantly different from that of rifabutin for organisms in lungs. The activity of azithromycin against several M. avium complex isolates was evaluated. The reduction of viable cell counts in spleens ranged from 1.7 to 0.8 log units. For the three isolates studied, there was little correlation between the in vitro MIC and the in vivo activity.
摘要
在播散性鸟分枝杆菌复合群感染的米色小鼠模型中，评估了阿奇霉素和克拉霉素的相对活性以及阿奇霉素单独使用和与其他抗分枝杆菌药物联合使用的活性。阿奇霉素的活性与克拉霉素相似。阿奇霉素加氯法齐明加乙胺丁醇比单独使用阿奇霉素更能减少脾脏中的菌量，而该联合用药对肺部细菌的活性低于单独使用阿奇霉素。利福布汀对脾脏和肺部的菌的活性与阿奇霉素相似。利福布汀加阿奇霉素对脾脏中的菌比任何一种药物单独使用时更具活性，但该联合用药对肺部菌的活性与利福布汀的活性无显著差异。评估了阿奇霉素对几种鸟分枝杆菌复合群分离株的活性。脾脏中活菌数的减少范围为1.7至0.8个对数单位。对于所研究的三株分离株，体外最低抑菌浓度与体内活性之间几乎没有相关性。
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