TLC G-65与其他药物联合用于米色小鼠鸟分枝杆菌感染的治疗。

TLC G-65 in combination with other agents in the therapy of Mycobacterium avium infection in beige mice.

作者信息

Cynamon M H, Klemens S P, Swenson C E

机构信息

Veterans Affairs Medical Center, Syracuse, New York.

出版信息

J Antimicrob Chemother. 1992 Jun;29(6):693-9. doi: 10.1093/jac/29.6.693.

DOI:10.1093/jac/29.6.693

PMID:1387133

Abstract

The activity of TLC G-65 (a liposomal gentamicin preparation), alone and in combination with rifapentine, clarithromycin, clofazimine and ethambutol, was evaluated in the beige mouse (C57BL/6J--bgj/bgj) model of disseminated Mycobacterium avium infection. TLC G-65 was found to be more active than amikacin. The combination of rifapentine and TLC G-65 was more active than either agent alone. The activity of clarithromycin in combination with TLC G-65 was similar to that of either agent alone. Clofazimine improved the activity of TLC G-65 with respect to the spleen, while ethambutol improved the activity with respect to the liver. Clofazimine and ethambutol enhanced the activity of TLC G-65 against bacteria in the lungs. TLC G-65 in combination with rifapentine appears to be an attractive regimen for the treatment of infections caused by bacteria in the M. avium complex.

摘要

在播散性鸟分枝杆菌感染的米色小鼠（C57BL/6J--bgj/bgj）模型中，评估了TLC G-65（一种脂质体庆大霉素制剂）单独以及与利福喷汀、克拉霉素、氯法齐明和乙胺丁醇联合使用时的活性。发现TLC G-65比阿米卡星更具活性。利福喷汀与TLC G-65联合使用比单独使用任何一种药物更具活性。克拉霉素与TLC G-65联合使用的活性与单独使用任何一种药物时相似。氯法齐明提高了TLC G-65对脾脏的活性，而乙胺丁醇提高了其对肝脏的活性。氯法齐明和乙胺丁醇增强了TLC G-65对肺部细菌的活性。TLC G-65与利福喷汀联合使用似乎是治疗鸟分枝杆菌复合群细菌引起的感染的一种有吸引力的方案。