Klemens S P, Cynamon M H
Veterans Affairs Medical Center, Syracuse, New York 13210.
Antimicrob Agents Chemother. 1991 Oct;35(10):2026-30. doi: 10.1128/AAC.35.10.2026.
The comparative activities of newer rifamycin analogs and the activity of rifabutin or rifapentine in combination with other antimycobacterial agents was evaluated in the beige (C57BL/6J; bgj/bgj) mouse model of disseminated Mycobacterium avium infection. Rifabutin and rifapentine at 20 mg/kg of body weight had comparable activities. P/DEA and CGP 7040 at 20 mg/kg were less active. The combination of ethambutol at 125 mg/kg and rifabutin at 20 mg/kg resulted in a slight increase in activity beyond that seen with rifabutin alone against organisms in the spleens. The combination of ethambutol and rifapentine at 20 mg/kg resulted in a modest increase in activity beyond that seen with rifapentine alone against organisms in the lungs. The combination of ethionamide at 125 mg/kg and rifapentine resulted in a decrease in activity compared with that for rifapentine alone. The combination of clofazimine at 20 mg/kg and rifapentine resulted in increased activity in the mouse model. The combination of clofazimine and rifapentine (or rifabutin) appears to be an attractive regimen that should be evaluated for the treatment of human infections due to M. avium complex.
在米色（C57BL/6J；bgj/bgj）小鼠播散性鸟分枝杆菌感染模型中，评估了新型利福霉素类似物的比较活性以及利福布汀或利福喷汀与其他抗分枝杆菌药物联合使用的活性。体重20mg/kg的利福布汀和利福喷汀具有相当的活性。20mg/kg的P/DEA和CGP 7040活性较低。125mg/kg的乙胺丁醇与20mg/kg的利福布汀联合使用，对脾脏中的细菌的活性比单独使用利福布汀略有增加。20mg/kg的乙胺丁醇和利福喷汀联合使用，对肺部细菌的活性比单独使用利福喷汀有适度增加。125mg/kg的乙硫异烟胺与利福喷汀联合使用，与单独使用利福喷汀相比活性降低。20mg/kg的氯法齐明与利福喷汀联合使用，在小鼠模型中活性增加。氯法齐明与利福喷汀（或利福布汀）联合使用似乎是一种有吸引力的治疗方案，应评估其用于治疗鸟分枝杆菌复合群引起的人类感染。
