两种研究性氟喹诺酮类药物（CI-960和E4695）对100多种军团菌分离株的抗菌活性。
Antimicrobial activities of two investigational fluoroquinolones (CI-960 and E4695) against over 100 Legionella sp. isolates.
作者信息
Gooding B B, Erwin M E, Barrett M S, Johnson D M, Jones R N
机构信息
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
出版信息
Antimicrob Agents Chemother. 1992 Sep;36(9):2049-50. doi: 10.1128/AAC.36.9.2049.
Abstract
The antimicrobial activities of two investigational fluoroquinolones (CI-960 and E4695) were compared with those of five similar compounds and four comparison drugs against 103 strains of Legionella pneumophila and five other Legionella species type strains. When concentrations inhibiting 90% of strains tested (MIC90s) for L. pneumophila were determined, CI-960 and temafloxacin emerged as the most active (0.015 microgram/ml) and were followed in potency by E4695 (0.03 microgram/ml). This activity was two- to fourfold greater than that of the reference drug, ciprofloxacin, and approached that of rifampin (MIC90, 0.008 microgram/ml). All fluoroquinolones studied were more active than erythromycin (MIC90, 0.5 microgram/ml). These two investigational fluoroquinolones appear well suited for further in vivo study of legionellosis therapy.
摘要
将两种研究性氟喹诺酮类药物（CI-960和E4695）的抗菌活性与五种类似化合物及四种对照药物针对103株嗜肺军团菌菌株和五种其他军团菌属模式菌株的抗菌活性进行了比较。在测定对嗜肺军团菌抑制90%受试菌株的浓度（MIC90）时，CI-960和替马沙星表现出最强活性（0.015微克/毫升），其次是E4695（0.03微克/毫升）。该活性比对照药物环丙沙星高两至四倍，接近利福平的活性（MIC90，0.008微克/毫升）。所有研究的氟喹诺酮类药物均比利福平更具活性（MIC90，0.5微克/毫升）。这两种研究性氟喹诺酮类药物似乎非常适合进一步用于军团病治疗的体内研究。
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