Helms C M, Massanari R M, Zeitler R, Streed S, Gilchrist M J, Hall N, Hausler W J, Sywassink J, Johnson W, Wintermeyer L, Hierholzer W J
Ann Intern Med. 1983 Aug;99(2):172-8. doi: 10.7326/0003-4819-99-2-172.
Over a 10-month period, 24 cases of Legionnaires' disease pneumonia occurred among patients admitted to an Iowa hospital, most of whom were immunosuppressed. Eleven patients died. Twenty-one patients were admitted to a recently completed hospital addition, 16 of these to a new hematology-oncology unit. Legionella pneumophila serogroup 1 was isolated from the patients, water outlets, and hot water in the new addition. Water quality variables in the hospital addition were adequate. Shock chlorination, temporary elevation of the hot water temperature, and continuous chlorination of hospital water decreased the frequency of isolation of Legionella. Water use by patients in the hematology-oncology unit was restricted until the water was free of Legionella. The incidence of Legionnaires' disease decreased. Indirect evidence supports an hypothesis of water-borne disease in this cluster of cases. Current variables of acceptable water potability may not guarantee water free of L. pneumophila.
在10个月的时间里，爱荷华州一家医院收治的患者中发生了24例军团病肺炎，其中大多数患者免疫功能低下。11名患者死亡。21名患者被收治到最近建成的医院新楼，其中16人被收治到新的血液肿瘤病房。从新楼的患者、出水口和热水中分离出嗜肺军团菌1型。医院新楼的水质变量是达标的。对医院用水进行冲击氯化、临时提高热水温度以及持续氯化，降低了军团菌的分离频率。在血液肿瘤病房的用水中军团菌清除之前，限制患者用水。军团病的发病率下降了。间接证据支持了这一系列病例中水源性疾病的假说。目前可接受的饮用水变量可能无法保证水中无嗜肺军团菌。
