Kobayashi K
First Dept. of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Gan To Kagaku Ryoho. 1992 Oct;19(12):1947-52.
Recently the number of hepatitis C virus antibody (HCV-Ab) positive male cases with hepatocellular carcinoma (HCC) is increasing only in Japan mainly for two reasons. One is that cases with liver cirrhosis are surviving longer than before. The other is the increasing number of HCC cases receiving blood transfusions at operations approximately 30 years ago. The prognosis of NS' 4 positive cases was worse than NS' 4 negative cases with HCV-Ab positive chronic hepatitis. The rate of HCV-Ab and HBsAg positive cases among 113 ones with HCC was about 70 percent and 25 percent, respectively. Some 239 cases with cirrhosis were followed for 6 years. Consequently HCV-Ab positive HCC cases were found to have a yearly incidence rate of 7 percent. The rate of development to HCC with HCV-Ab and HBsAg positive cases was significantly higher than that of both HCV-Ab and HBsAg negative ones. The integration of HCV-RNA was not found both in cancerous and non-cancerous region, different from the very high integration rate of HBsAg positive cases. Pathoepidemiologically, HCV is closely related to HCC. However, the role of HCV in the development of HCC remains unknown.
最近，仅在日本，丙型肝炎病毒抗体（HCV-Ab）阳性的男性肝细胞癌（HCC）病例数量正在增加，主要有两个原因。一是肝硬化患者的存活时间比以前更长。另一个是大约30年前在手术中接受输血的HCC病例数量不断增加。HCV-Ab阳性慢性肝炎患者中，NS'4阳性病例的预后比NS'4阴性病例更差。在113例HCC患者中，HCV-Ab和HBsAg阳性病例的比例分别约为70%和25%。对约239例肝硬化患者进行了6年的随访。结果发现，HCV-Ab阳性的HCC病例年发病率为7%。HCV-Ab和HBsAg阳性病例发展为HCC的比例明显高于HCV-Ab和HBsAg均阴性的病例。与HBsAg阳性病例的高整合率不同，在癌组织和非癌组织中均未发现HCV-RNA的整合。从病理流行病学角度来看，HCV与HCC密切相关。然而，HCV在HCC发生发展中的作用仍不清楚。
