幼年新西兰黑鼠的T细胞功能亢进；对同种异体细胞的增殖反应增强。
Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells.
作者信息
Palmer D W, Dauphinée M J, Murphy E, Talal N
出版信息
Clin Exp Immunol. 1976 Mar;23(3):578-81.
The one-way mixed lymphocyte reaction was employed to study proliferative responses to antigens by mature, immunocompetent T cells from NZB mice 3 weeks to 4 months old. Compared to cells from control mice of the same H-2 type, thymus, spleen and lymph node cells from NZB mice were hyperactive in this response. The results are discussed in relation to possible effects of chronic stimulation by endogenous type C leukaemia virus upon differentiation of functional T cells or upon regulation by T cells of other T-cell functions, including augmentation of antibody responses.
采用单向混合淋巴细胞反应来研究3周龄至4月龄的NZB小鼠成熟的、具有免疫活性的T细胞对抗原的增殖反应。与相同H-2类型对照小鼠的细胞相比，NZB小鼠的胸腺、脾脏和淋巴结细胞在这种反应中表现出过度活跃。结合内源性C型白血病病毒的慢性刺激对功能性T细胞分化或对其他T细胞功能（包括抗体反应增强）的T细胞调节的可能影响，对结果进行了讨论。
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