T细胞替代因子对体外IgG抗体应答的刺激作用。
Stimulation of IgG antibody response in vitro by T cell-replacing factor.
作者信息
Schimpl A, Wecker E
出版信息
J Exp Med. 1973 Feb 1;137(2):547-52. doi: 10.1084/jem.137.2.547.
Abstract
A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.
摘要
由同种异体小鼠脾脏、淋巴结和胸腺细胞混合物产生的一种可溶性因子（TRF），在体外对绵羊血细胞的初次IgM抗体应答中，在功能上可替代T细胞。现已表明，TRF还能在源自预先免疫小鼠的无T细胞脾脏培养物中重建IgG抗体应答。初次和二次体外系统中TRF添加的最佳时间和所需量有所不同。
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